A Dreamworks animation film, Monsters Vs. Aliens features a host of stars including Reese Witherspoon, Seth Rogen, Kiefer Sutherland and Will Arnett and is helmed by Rob Lettermen (Shark Tale) and Conrad Vernon (Shrek 2).

When California girl Susan Murphy (Reece Witherspoon) is unexpectedly hit by a meteor full of outer space gunk, she mysteriously grows to 49-feet-11-inches tall and is instantly labeled a "monster" named Ginormica. The military jumps into action, and she is captured and held in a secret government compound. The world learns that the military has been quietly rounding up other monsters over the years. This ragtag group consists of the brilliant but insect-headed Dr. Cockroach, Ph.D. (Hugh Laurie); the macho half-ape, half-fish The Missing Link (Will Arnett); the gelatinous and indestructible B.O.B. (Seth Rogan); and the 350-foot grub called Insectosaurus. Their confinement time is cut short however, when a mysterious alien robot lands on Earth and begins storming the country.

As a last resort, under the guidance of General W.R. Monger (Kiefer Sutherland) - on a desperate order from The President (Stephen Colbert), the motley crew of Monsters is called into action to combat the aliens and save the world from imminent destruction.