Presenting information on the selection and application of biochemical tests in safety assessment studies, seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies.

By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science.

• Study design and regulatory requirements
• pre
• analytical and analytical variables
• statistical approaches
• enzymes
• assessment of hepatotoxicity
• assessment of nephrotoxicity
• assessment of endocrine toxicity
• assessment of gastrointestinal toxicity
• assessment of cardiotoxicity and myotoxicity
• assessment of neurotoxicity
• electrolytes
• lipids
• proteins